Application of Next Genaration Sequencing Upon the detection of Deafness Genes in Vietnamese Children with Non-syndromic Hearing Loss

Introduction: there are 15000 hearing impaired children are born in Vietnam every year. Early detection of common deafness mutations is a key factor for diagnosing and helping hearing loss children to develop their language and awareness normally. Objective: to identify the carier rate of common deafness mutations in Vietnamese popultion Objects and methods: 80 hearing impaired and 100 hearing normal children in Vietnam. Apply techology of next generation sequencing to detect 100 mutations of 18 deafness genes, namely: GJB2, GJB3, SLC26A4, MT-RNR1, MT-CO1. MT- TL1, MT-TS1, MT-TH, DSPP, GPR98, DFNAS,, TMC1, MYO7A, TECTA, DIABLO, COACH, MYO15A and PAPS1